加拿大lpc28
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Whereas co-stimulation of the T-cell antigen receptor (TCR) and CD28 triggers T-cell activation, stimulation of the TCR alone may result in an anergic state or T-cell deletion, both possible mechanisms of tolerance induction1,2 Here we show that T cells that are deficient in the adaptor molecule Cbl-b (ref 3) do not require CD28 engagement for interleukin-2 production, and that the Cbl-b-null mutation (Cbl-b-/-) fully restores T-cell-dependent antibody responses in CD28-/-mice The main TCR signalling pathways, such as tyrosine kinases Zap-70 and Lck, Ras/mitogen-activated kinases, phosp
在COP28上可能会引起关注的另一个话题是损失与损害基金的进展。发达国家应该向该基金注资,用于支持发展中国家应对气候变化造成的不可挽回
2000Macmillan Magazines Ltd letters nature216 NATURE VOL403 13JANUARY 2000 cellswere stimulated hamsteranti-CD3e (clone 145-2C11, hamster IgG; PharMingen) hamsteranti-CD3e (clone 145-2C11) plus hamster anti-CD28 (clone 3751; PharMingen) varioustimes Cells were lysed ice-coldlysis buffer (10mMTris-HCl pH75, 1mMMgCl 05%CHAPS,1mMEDTA, 10%glycerol, 100mM Na 50mMNaF, 20mg ml -1 leupeptin 1mMbenzamidine)Whole-cell lysates immunoprecipitates(IPs) were separated SDSpolyacrylamidegels proteinswere transferred nitroc
span style= font-family:Times,serif;font-size:9pt; The CD282 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells CD28 is a costimulatory receptor that binds CD80 and CD86 as ligands and plays a very important role in T cell-B cell interactions It has been suggested that CD28 initiates and regulates a separate and distinct signal transduction pathway from those stimulated by the TCR complex Additionally, it has been reported that CD28 antibody clones vary in their ability to stimu
产品货号:61R-CD28dMSFT 规格:500 ug 报价: 折后价: 数量: 说明书* 以下信息仅供参考,详情请以原厂网站为准 CD28 antibody (FITC) Hamster monoclonal CD28 antibody (FITC) Hamster FC IgG CD28 antibody (FITC) was raised in hamster using CD28 costimulatory receptor as the immunogen 3751 FITC 05 mg/ml Store at 4 deg C *Blue Ice* Supplied as a liquid in PBS, with NaN3 added as preservative 美国 Supplied as a liquid in PBS, with NaN3 added as preservative 最新促销 一文了解自身免疫性疾病生物标志物—APRIL & BAFFBioXCell热销产品--InVivoMAb anti-mouse myelo
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